Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27440295 | 0.86 | HPGD (0.65) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1422207 | 0.82 | ALDH1A1 (0.63) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11195052 | 0.82 | HPGD (0.63) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2693058 | 0.82 | HDAC8 (0.58) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4149990 | 0.81 | HPGD (0.61) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9028983 | 0.81 | HPGD (0.61) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23647680 | 0.79 | SMN1; SMN2 (0.59) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13545194 | 0.79 | KDM4E (0.59) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6014610 | 0.79 | HPGD (1.00) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2691033 | 0.79 | HDAC1 (0.74) | HPGDSMN1; SMN2ALDH1A1LMNAHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013041407-A1 | HYDROXAMIC ACIDS AS HDAC6 INHIBITORS | CELLZOME AG (DE) | 2013-03-28 | — | — | WO | claimed |
| WO-2013041407-A1 | HYDROXAMIC ACIDS AS HDAC6 INHIBITORS | CELLZOME AG (DE) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013041407-A1 | HYDROXAMIC ACIDS AS HDAC6 INHIBITORS | CELLZOME AG (DE) | 2013-03-28 | — | — | WO | disclosed |
| EP-1140085-B1 | AZABICYCLOALKANES AS CCR5 MODULATORS | PHIVCO UK LTD (GB) | 2011-04-13 | — | — | EP | disclosed |
| US-6586430-B1 | Administering azabicyclo compounds to treat human immunodeficiency virus infections and respiratory system disorders | PFIZER INC. | 2003-07-01 | — | — | US | disclosed |