Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560601 | 0.88 | HPGD (0.58) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL11195052 | 0.85 | HPGD (0.63) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL9028983 | 0.84 | HPGD (0.61) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL4149990 | 0.84 | HPGD (0.61) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL1421898 | 0.84 | HPGD (0.65) | ALDH1A1HPGDLMNAHTTSMN1; SMN2 | |
| SCHEMBL397628 | 0.83 | HPGD (0.56) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL23647680 | 0.82 | SMN1; SMN2 (0.59) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL13545194 | 0.82 | KDM4E (0.59) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL1574068 | 0.82 | KDM4E (0.65) | ALDH1A1HPGDKDM4ELMNAHTT | |
| SCHEMBL657740 | 0.82 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12534451-B2 | Small molecule modulators of PanK | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2026-01-27 | — | — | US | disclosed |
| CN-113666853-B | Biaryl compounds useful as ROR gamma modulators | 上海辉启生物医药科技有限公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20220185796-A1 | SMALL MOLECULE MODULATORS OF PANK | ST. JUDE CHILDREN'S RESEARCH HOSPITAL | 2022-06-16 | — | — | US | disclosed |
| EP-3946312-A2 | SMALL MOLECULE MODULATORS OF PANK | St. Jude Children's Research Hospital (US) | 2022-02-09 | — | — | EP | disclosed |
| CN-113666853-A | Biaryl compounds useful as ROR gamma modulators | 上海辉启生物医药科技有限公司 | 2021-11-19 | — | — | CN | disclosed |
| CN-112920180-A | Glutaminase inhibitors | 理森制药股份公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-108863850-B | Biaryl compound and preparation method and application thereof | 复旦大学 | 2021-05-18 | — | — | CN | disclosed |
| CN-105960405-B | Glutaminase inhibitors | 理森制药股份公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2020198526-A2 | SMALL MOLECULE MODULATORS OF PANK | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-10-01 | — | — | WO | disclosed |
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2002026722-A1 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
| WO-2002016319-A1 | NOVEL THIOUREA COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2002-02-28 | — | — | WO | disclosed |
| US-6265445-B1 | CARDIOVASCULAR DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 2001-07-24 | — | — | US | disclosed |
| CN-1284941-A | Novel antiarrhythmic compounds | PHARMACEUTICAL RES INST PUBLIC (HU) | 2001-02-21 | — | — | CN | disclosed |
| EP-1037871-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029655-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | Gyógyszerkutató Intézet Kft. (HU) | 1999-06-17 | — | — | WO | disclosed |
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4855314-A | VASOCONTRICTORS, TREATMENT OF MIGRAINES, 3-(AMINO-ETHYL)-5-(PHENYL(ALKYL)-CARBONYL OR SULFONYL-AMINOALKYL SUBSTITUTED | GLAXO GROUP LIMITED (GB) | 1989-08-08 | — | — | US | disclosed |
| EP-0240096-A1 | Indole derivatives having a selective vasoconstrictor activity | GLAXO GROUP LIMITED (GB) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12534451-B2 | Small molecule modulators of PanK | PANK2, PANK1, PANK3 | ALDH1A1 3157/4885HPGD 539/4885KDM4E 2808/4885 |
| US-20220185796-A1 | SMALL MOLECULE MODULATORS OF PANK | PANK2, PANK1, PANK3 | ALDH1A1 4174/4885HPGD 825/4885KDM4E 2487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.