Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574703 | 1.00 | PRMT5 (0.35) | PRMT5WDR77CHRM3CHRM2HSD11B1 | |
| SCHEMBL75413 | 0.82 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL75794 | 0.71 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL5319749 | 0.65 | KDM4E (0.38) | CHRM2HSD11B1TSHRCYP3A4CYP2D6 | |
| SCHEMBL75342 | 0.64 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL4078948 | 0.62 | HSD11B1 (0.38) | CHRM3CHRM2HSD11B1LMNA | |
| SCHEMBL4079102 | 0.60 | HSD11B1 (0.44) | HSD11B1TSHR | |
| SCHEMBL75455 | 0.59 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL75243 | 0.58 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL1069807 | 0.58 | TACR1 (0.49) | TSHRCYP2C19CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308851-A1 | Imidazolone and imidazolidinone derivatives as 11B-HSD1 inhibitors for the treatment of diabetes | F. Hoffmann-La Roche AG (CH) | 2011-04-13 | — | — | EP | disclosed |