Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15747769 | 0.88 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP2C19NPC1RAB9AJAK2 | |
| SCHEMBL15747839 | 0.87 | CA1 (0.44) | SMN1; SMN2CYP2C19HTTAURKBHDAC1 | |
| SCHEMBL15747823 | 0.83 | LNPEP (0.44) | SMN1; SMN2CYP2C19AURKBHDAC1 | |
| SCHEMBL15747864 | 0.78 | HDAC1 (0.37) | SMN1; SMN2CYP2C19AURKBHDAC1 | |
| SCHEMBL25329767 | 0.77 | SMN1; SMN2 (0.64) | SMN1; SMN2CYP2C19NPC1RAB9AJAK2 | |
| SCHEMBL15747771 | 0.76 | GRIN2B (0.42) | SMN1; SMN2CYP2C19NPC1RAB9AJAK2 | |
| SCHEMBL15747763 | 0.76 | PIK3CA (0.42) | SMN1; SMN2CYP2C19NPC1RAB9AJAK2 | |
| SCHEMBL15747857 | 0.75 | CA1 (0.42) | SMN1; SMN2HTT | |
| SCHEMBL15747803 | 0.73 | SMN1; SMN2 (0.64) | SMN1; SMN2CYP2C19NPC1RAB9AJAK2 | |
| SCHEMBL31198975 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP2C19NPC1RAB9AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014079364-A1 | IMIDAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 北京富龙康泰生物技术有限公司 (CN) | 2014-05-30 | — | — | WO | disclosed |