Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15742146 | 0.81 | CDC7 (0.51) | DGAT1CYP19A1PTGER2CDC7FFAR4 | |
| SCHEMBL6957897 | 0.78 | KCNH2 (0.52) | MCHR1CYP19A1KCNH2FFAR4 | |
| SCHEMBL6654267 | 0.76 | ROCK1 (0.48) | DGAT1CYP19A1KCNH2CDC7ROCK1 | |
| SCHEMBL6658922 | 0.74 | CYP17A1 (0.41) | DGAT1CYP19A1CDC7 | |
| SCHEMBL15742555 | 0.73 | CYP2A6 (0.50) | DGAT1CYP19A1KCNH2ROCK1ELANE | |
| SCHEMBL15178557 | 0.73 | DGAT1 (0.46) | DGAT1CYP19A1KCNH2FFAR4ROCK1 | |
| SCHEMBL6840208 | 0.72 | RXRA (0.48) | DGAT1PTK2FFAR4 | |
| SCHEMBL694549 | 0.72 | DGAT1 (0.40) | DGAT1CYP19A1KCNH2ELANE | |
| SCHEMBL29700887 | 0.71 | GAA (0.40) | — | |
| SCHEMBL1688808 | 0.71 | GAA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014081996-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-05-30 | — | — | WO | disclosed |