Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 4/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083302 | 0.81 | KCNH2 (0.56) | KCNH2KDM4ELMNAHTTEPHX2 | |
| SCHEMBL3785456 | 0.81 | KCNH2 (0.56) | KCNH2KDM4ELMNAEPHX2MGLL | |
| SCHEMBL6956593 | 0.81 | KCNH2 (0.56) | KCNH2KDM4ELMNAHTTEPHX2 | |
| SCHEMBL6583376 | 0.78 | KCNH2 (0.56) | KCNH2KDM4ELMNAHTTEPHX2 | |
| SCHEMBL15748447 | 0.78 | DGAT1 (0.42) | KCNH2MCHR1FFAR4CYP19A1 | |
| SCHEMBL5737044 | 0.76 | KCNH2 (0.51) | KCNH2KDM4ELMNAHTTEPHX2 | |
| SCHEMBL5735700 | 0.74 | KCNH2 (0.49) | KCNH2KDM4ELMNAEPHX2MGLL | |
| SCHEMBL4296315 | 0.72 | KCNH2 (0.60) | KCNH2KDM4EEPHX2MGLLMAPT | |
| SCHEMBL22204996 | 0.72 | KCNH2 (0.60) | KCNH2KDM4EEPHX2MGLLMAPT | |
| SCHEMBL4572982 | 0.72 | KCNH2 (0.60) | KCNH2LMNAHTTEPHX2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |