Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960150 | 0.88 | GAA (0.41) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL16020729 | 0.87 | BCHE (0.44) | GAAKMT2AALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL157494 | 0.86 | STAT3 (0.43) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL3315459 | 0.85 | GAA (0.52) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 | |
| Fluoride SCHEMBL31533364 | 0.83 | GAA (0.50) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 | |
| Butane SCHEMBL1393934 | 0.82 | STAT3 (0.40) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8758128 | 0.82 | EEF2K (0.43) | SMN1; SMN2KMT2AALDH1A1CYP3A4CA1 | |
| SCHEMBL28684539 | 0.81 | PARL (0.42) | GAASMN1; SMN2KMT2AALDH1A1CA1 | |
| SCHEMBL9905506 | 0.81 | C5AR1 (0.38) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL11604749 | 0.81 | GAA (0.48) | GAASTAT3SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733896-A | VIRICIDE FOR RETROVIRUS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1998-03-31 | — | — | US | claimed |
| EP-0253412-A2 | N-Phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity | Ceskoslovenska akademie ved (CS) | 1988-01-20 | — | — | EP | claimed |
| CN-120022913-A | Method for using high-stability copper-based catalyst in hydrochlorination of acetylene | 中盐吉兰泰氯碱化工有限公司 | 2025-05-23 | — | — | CN | disclosed |
| EP-3020720-B1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX INC (US) | 2018-09-19 | — | — | EP | disclosed |
| CN-105998039-A | Phosphonate ester derivatives and methods of synthesis thereof | 奇默里克斯公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-2611818-B1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | CHIMERIX INC (US) | 2016-08-24 | — | — | EP | disclosed |
| CN-103209985-B | Phosphonate derivatives and methods of synthesis thereof | 奇默里克斯公司 | 2016-08-24 | — | — | CN | disclosed |
| EP-3020720-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | Chimerix, Inc. (US) | 2016-05-18 | — | — | EP | disclosed |
| US-9303051-B2 | Phosphonate ester derivatives and methods of synthesis thereof | CHIMERIX INC. (US) | 2016-04-05 | — | — | US | disclosed |
| CN-105218580-A | Phosphate derivatives and synthetic method thereof | CHIMERIX INC | 2016-01-06 | — | — | CN | disclosed |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | EMERGENT BIODEFENSE OPERATIONS LANSING LLC | 2015-11-19 | — | — | US | disclosed |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | CHIMERIX, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| EP-2086990-A2 | NOVEL NUCLEOTIDE ANALOGUES AS PERCURSOR MOLECULES FOR ANTIVIRALS | Centre National De La Recherche Scientifique-CNRS (FR) | 2009-08-12 | — | — | EP | disclosed |
| EP-2016062-A2 | ANTI-VIRAL AGENTS THAT ACTIVATE RNASE L | The Cleveland Clinic Foundation (US) | 2009-01-21 | — | — | EP | disclosed |
| US-7388002-B2 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
| WO-2008056264-A2 | NOVEL NUCLEOTIDE ANALOGUES AS PERCURSOR MOLECULES FOR ANTIVIRALS | CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-05-15 | — | — | WO | disclosed |
| WO-2007127212-A2 | ANTI-VIRAL AGENTS THAT ACTIVATE RNASE L | THE CLEVELAND CLINIC FOUNDATION (US) | 2007-11-08 | — | — | WO | disclosed |
| WO-2006076015-A2 | 1-[2-(PHOSPHONOMETHOXY)ETHYL]-CYTOSINE AND ANALOGS THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-07-20 | — | — | WO | disclosed |
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
| WO-2005087788-A2 | METHODS FOR PREPARATION OF NUCLEOSIDE PHOSPHONATE ESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | POLR2H, NSUN2, POLR2E | GAA 2605/4885STAT3 2322/4885SMN1; SMN2 655/4885 |
| US-20120058976-A1 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof | PHOSPHO1, PIK3CA, PNP | GAA 507/4885STAT3 3774/4885SMN1; SMN2 2752/4885 |
| US-20150329575-A1 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF | PHOSPHO1, PIK3CA, PNP | GAA 507/4885STAT3 3774/4885SMN1; SMN2 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.