Urea

Urea

SCHEMBL1576419

NC(N)=O.O=CNc1ncccn1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.39
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
ALDH1A1 P00352 4/20 0.38
KDM4E B2RXH2 2/20 0.33
FFAR2 O15552 1/20 0.33
GAA P10253 1/20 0.33
KDM5A P29375 1/20 0.32
JMJD1C Q15652 1/20 0.32
KDM3A Q9Y4C1 1/20 0.32
PARP1 P09874 1/20 0.32
NPC1 O15118 1/20 0.32
PKM P14618 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20909 0.89
SCHEMBL1594378 0.70 LMNA (0.52) P2RX7LMNAHTTALDH1A1KDM4E
SCHEMBL8320889 0.68 LMNA (0.50) P2RX7LMNAHTTALDH1A1KDM4E
Hydrochloric Acid SCHEMBL29102678 0.68 LMNA (0.50) P2RX7LMNAHTTALDH1A1KDM4E
Benzene SCHEMBL29287884 0.68 ALDH1A1 (0.41) ALDH1A1
SCHEMBL11129959 0.68 LMNA (0.37) P2RX7LMNAHTTALDH1A1KDM4E
SCHEMBL1007994 0.67
SCHEMBL18891261 0.67 SCN9A (0.46) KDM4EKDM5AJMJD1CKDM3A
SCHEMBL23566413 0.64 LMNA (0.56) LMNAHTTALDH1A1KDM4EGAA
SCHEMBL28879420 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1430145-A4 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RES & DEV (IL) 2006-08-16 EP claimed
EP-1430145-A2 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) 2004-06-23 EP claimed
US-20040096863-A1 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a dna repair enzyme and a cancer YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-05-20 US claimed
US-20030003454-A1 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a DNA repair enzyme and a cancer YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE 2003-01-02 US claimed
WO-2002076280-A2 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2002-10-03 WO claimed
EP-1430145-B1 METHODS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RES & DEV (IL) 2013-01-02 EP disclosed
US-8043807-B2 For diagnosis/prognosis; kits; drugs/radiotherapy YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2011-10-25 US disclosed
EP-2308994-A1 Methods for determining a risk to develop cancer YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 2011-04-13 EP disclosed
EP-1430145-A4 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RES & DEV (IL) 2006-08-16 EP disclosed
EP-1430145-A2 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) 2004-06-23 EP disclosed
US-20040096863-A1 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a dna repair enzyme and a cancer YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-05-20 US disclosed
US-20030003454-A1 Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a DNA repair enzyme and a cancer YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE 2003-01-02 US disclosed
WO-2002076280-A2 METHODS AND KITS FOR DETERMING A RISK TO DEVELOP CANCER, FOR EVALUATING AN EFFECTIVENESS AND DOSAGE OF CANCER THERAPY AND FOR CORRELATING BETWEEN AN ACTIVITY OF A DNA REPAIR ENZYME AND A CANCER YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2002-10-03 WO disclosed