SCHEMBL1576854

SCHEMBL1576854

COc1nc(N)nc(N(C)C)n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.44
GAA P10253 2/20 0.44
ALDH1A1 P00352 3/20 0.43
CYP1A2 P05177 3/20 0.42
LMNA P02545 2/20 0.42
THRB P10828 1/20 0.42
BLM P54132 1/20 0.42
CREBBP Q92793 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TSHR P16473 2/20 0.41
HTT P42858 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
GFER P55789 1/20 0.40
CTSK P43235 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GLA P06280 1/20 0.39
POLB P06746 1/20 0.39
SMARCA2 P51531 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11795651 0.84 CYP1A2 (0.53) GAAALDH1A1CYP1A2LMNATHRB
SCHEMBL139336 0.78 LMNA (0.59) RECQLGAAALDH1A1CYP1A2LMNA
SCHEMBL138352 0.78 HSD17B10 (0.44) RECQLGAAALDH1A1LMNAHSD17B10
SCHEMBL593463 0.78 HSD17B10 (0.69) RECQLGAAALDH1A1CYP1A2LMNA
SCHEMBL1576395 0.78 TSHR (0.44) RECQLGAAALDH1A1LMNAHSD17B10
SCHEMBL4616571 0.78 TP53 (0.34) GAAALDH1A1HSD17B10TSHRHTT
SCHEMBL7804027 0.76 ALDH1A1 (0.39) RECQLALDH1A1CYP1A2LMNATHRB
SCHEMBL27832367 0.76 GAA (0.45) GAAALDH1A1CYP1A2LMNATHRB
SCHEMBL7808647 0.74 ALDH1A1 (0.37) RECQLALDH1A1CYP1A2LMNATHRB
SCHEMBL27738398 0.74 ALDH1A1 (0.37) RECQLALDH1A1CYP1A2LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011039276-A1 OXATHIAZINYL(HET)ARYLSULFONYLUREAS, PROCESSES AND INTERMEDIATES FOR PREPARATION THEREOF AND USE THEREOF AS CROP PROTECTION AGENTS AND CROP GROWTH REGULATORS BAYER CROPSCIENCE AG (DE) 2011-04-07 WO disclosed
US-5847126-A N-azinyl-N'-(het) arylsulphonyl-ureas BAYER AKTIENGESELLSCHAFT (DE) 1998-12-08 US disclosed
EP-0645386-B1 N-Azinyl-N'-(het)arylsulfonylureas as herbicides BAYER AG (DE) 1997-12-29 EP disclosed
US-5696257-A INTERMEDIATES FOR HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-09 US disclosed
US-5580842-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1996-12-03 US disclosed
US-5476936-A Herbicides BAYER AKTIENGESELLSCHAFT (DE) 1995-12-19 US disclosed
EP-0645386-A1 N-Azinyl-N'-(het)arylsulfonylureas as herbicides BAYER AG (DE) 1995-03-29 EP disclosed
US-5401710-A SULFONAMIDOPYRIMIDINES FOR COMBATTING WEEDS SCHERING AGROCHEMICALS LIMITED (GB) 1995-03-28 US disclosed
EP-0566621-A1 HERBICIDES AgrEvo UK Limited (GB) 1993-10-27 EP disclosed
WO-1992011763-A1 HERBICIDES SCHERING AGROCHEMICALS LIMITED (GB) 1992-07-23 WO disclosed
US-4655821-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-04-07 US disclosed
US-4656273-A Process for producing sulfonylureas CIBA-GEIGY CORPORATION (US) 1987-04-07 US disclosed
US-4543120-A HERBICIDES, PLATN GROWTH REGULANTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-09-24 US disclosed
EP-0152378-A2 Herbicidal sulfonylureas CIBA-GEIGY AG (CH) 1985-08-21 EP disclosed
EP-0132230-A2 Process for the preparation of sulfonyl urea CIBA-GEIGY AG (CH) 1985-01-23 EP disclosed
EP-0101308-A2 Alkyl sulfonyl sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-02-22 EP disclosed
EP-0010560-B1 HERBICIDAL SULFONAMIDES, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND USE THEREOF E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-04-13 EP disclosed
US-4231784-A PRE- AND POSTEMERGENCE HERBICIDES; PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-11-04 US disclosed
EP-0010560-A1 Herbicidal sulfonamides, their preparation, compositions containing them and use thereof E.I. DU PONT DE NEMOURS AND COMPANY (US) 1980-05-14 EP disclosed
US-4190432-A CONTROLLING VOLUNTEER CORN IN SOYBEANS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1980-02-26 US disclosed