Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 7/20 | 0.55 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499694 | 1.00 | HDAC4 (0.55) | HDAC4LTA4HHPGDSTNKSSLC9A1 | |
| SCHEMBL30788829 | 0.78 | SLC9A1 (0.53) | HDAC4SLC9A1 | |
| SCHEMBL15768718 | 0.74 | HDAC4 (0.53) | HDAC4SLC9A1 | |
| SCHEMBL12498720 | 0.74 | HDAC4 (0.53) | HDAC4SLC9A1 | |
| SCHEMBL15768592 | 0.74 | HDAC4 (0.58) | HDAC4SLC9A1BRD4 | |
| SCHEMBL15768593 | 0.74 | HDAC4 (0.58) | HDAC4SLC9A1BRD4 | |
| SCHEMBL12497988 | 0.73 | HDAC4 (0.55) | HDAC4TNKSSLC9A1 | |
| SCHEMBL15768691 | 0.73 | HDAC4 (0.55) | HDAC4TNKSSLC9A1 | |
| Acetic Acid SCHEMBL27259016 | 0.73 | HPGDS (0.59) | HDAC4LTA4HHPGDSFAAHCES1 | |
| SCHEMBL19366378 | 0.73 | HDAC4 (0.61) | HDAC4LTA4HHPGDSTNKSFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC7, HDAC5 | HDAC4 10/4885LTA4H 1736/4885HPGDS 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.