Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655662 | 0.84 | KMT2A (0.56) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL15775278 | 0.82 | MAPT (0.64) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL2446111 | 0.76 | EPHX1 (0.77) | MEN1KMT2ALMNAEPHX1KDM4E | |
| SCHEMBL14697664 | 0.75 | LMNA (0.60) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL19745686 | 0.75 | PTGS2 (0.56) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL9547553 | 0.75 | EPHX1 (0.83) | MEN1KMT2ALMNAEPHX1KDM4E | |
| SCHEMBL19420655 | 0.75 | EPHX1 (0.83) | MEN1KMT2ALMNAEPHX1KDM4E | |
| SCHEMBL14500260 | 0.75 | PKM (0.76) | MEN1KMT2AMAPTLMNAEPHX1 | |
| SCHEMBL502507 | 0.74 | MEN1 (0.81) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL11051077 | 0.73 | EPHX1 (0.70) | MEN1KMT2ALMNAEPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | claimed |
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | disclosed |