Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 10/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.67 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.67 |
| ▸ | GUSB | P08236 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20299026 | 0.88 | HPGD (0.71) | TNKSTNKS2PARP2GUSBHPGD | |
| SCHEMBL14344516 | 0.86 | KDM4C (0.80) | TNKSTNKS2PARP2GUSBHPGD | |
| SCHEMBL15775258 | 0.85 | TNKS (0.67) | TNKSTNKS2GUSBHPGDALDH1A1 | |
| SCHEMBL11080745 | 0.80 | TNKS (0.73) | TNKSTNKS2PARP2GUSBHPGD | |
| SCHEMBL8618931 | 0.80 | TNKS (1.00) | TNKSTNKS2PARP2GUSBHPGD | |
| SCHEMBL9694046 | 0.78 | ALDH1A1 (1.00) | HPGDALDH1A1KDM4ENPC1PKM | |
| SCHEMBL15775257 | 0.77 | ALDH1A1 (0.60) | TNKSTNKS2PARP2GUSBHPGD | |
| SCHEMBL14344501 | 0.76 | KDM4C (1.00) | TNKSTNKS2PARP2GUSBHPGD | |
| SCHEMBL11083849 | 0.75 | TNKS (0.65) | TNKSTNKS2PARP2GUSBNPC1 | |
| SCHEMBL15645718 | 0.75 | KDM4C (0.82) | TNKSTNKS2GUSBHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |