Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 8/20 | 0.62 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.62 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.62 |
| ▸ | GUSB | P08236 | 2/20 | 0.62 |
| ▸ | PARP1 | P09874 | 4/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775973 | 0.85 | TNKS (0.62) | TNKSTNKS2PARP2PARP1HCAR2 | |
| SCHEMBL14344541 | 0.85 | HCAR2 (0.56) | TNKSTNKS2PARP2GUSBPARP1 | |
| SCHEMBL15775723 | 0.82 | TNKS2 (0.65) | TNKSTNKS2PARP2PARP1HCAR2 | |
| SCHEMBL30897311 | 0.79 | HPGD (0.68) | TNKSTNKS2PARP1HCAR2ALDH1A1 | |
| SCHEMBL28693174 | 0.78 | AURKA (0.68) | — | |
| SCHEMBL20954965 | 0.78 | HCAR2 (0.59) | PARP1HCAR2HCAR3 | |
| Hydrochloric Acid SCHEMBL11772488 | 0.77 | AURKA (0.66) | — | |
| SCHEMBL8618931 | 0.77 | TNKS (1.00) | TNKSTNKS2PARP2GUSBPARP1 | |
| SCHEMBL15775287 | 0.77 | TNKS (0.51) | TNKSTNKS2PARP2GUSBPARP1 | |
| SCHEMBL16333375 | 0.76 | HCAR2 (0.59) | TNKSTNKS2PARP2PARP1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |