Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776205 | 0.86 | ADORA2A (0.55) | TNKSTNKS2PARP1AURKAALDH1A1 | |
| SCHEMBL15775972 | 0.85 | TNKS (0.51) | TNKSTNKS2PARP1AURKAALDH1A1 | |
| SCHEMBL15775720 | 0.82 | TNKS (0.54) | TNKSTNKS2PARP2PARP1RAB9A | |
| SCHEMBL3246330 | 0.79 | AURKA (0.53) | PARP1AURKAALDH1A1ADORA2AADORA1 | |
| SCHEMBL9692278 | 0.78 | KDM4E (0.54) | TNKSTNKS2PARP2GUSBMAPK1 | |
| SCHEMBL8618923 | 0.77 | TNKS (0.59) | TNKSTNKS2PARP2GUSBPARP1 | |
| Methane SCHEMBL9692076 | 0.77 | KDM4E (0.53) | TNKSTNKS2PARP2GUSBMAPK1 | |
| SCHEMBL15775288 | 0.77 | TNKS (0.62) | TNKSTNKS2PARP2GUSBPARP1 | |
| SCHEMBL3058184 | 0.76 | METAP2 (0.58) | PARP1AURKAALDH1A1HPGDKDM4E | |
| SCHEMBL15775257 | 0.73 | ALDH1A1 (0.60) | TNKSTNKS2PARP2GUSBPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |