Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1482406 | 0.84 | NR1H4 (0.48) | PTGER4PDE7APDE4BPDE4DALDH1A1 | |
| SCHEMBL1577603 | 0.83 | LMNA (0.39) | PTGER4KMT2AFBP1TSHRKDM4E | |
| SCHEMBL1577009 | 0.82 | PTGER4 (0.40) | PTGER4ALDH1A1KMT2AFBP1TSHR | |
| SCHEMBL1577098 | 0.80 | GRM2 (0.40) | PTGER4ALDH1A1FBP1KDM4E | |
| SCHEMBL1577470 | 0.78 | NR1H4 (0.40) | PTGER4ALDH1A1NR1H4 | |
| SCHEMBL1577478 | 0.77 | FBP1 (0.38) | PTGER4ALDH1A1FBP1KDM4E | |
| SCHEMBL1577199 | 0.75 | NPSR1 (0.40) | PTGER4ALDH1A1KMT2AFBP1KDM4E | |
| SCHEMBL1577202 | 0.75 | ALOX5 (0.43) | PTGER4SLC6A4HPGDNR1H4 | |
| SCHEMBL1577077 | 0.74 | CNR1 (0.39) | PTGER4FBP1 | |
| SCHEMBL1577421 | 0.74 | ALOX5 (0.43) | PTGER4FBP1SLC6A4NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483247-A1 | NEW BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011039130-A1 | NEW BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-07 | — | — | WO | disclosed |