Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577483 | 0.86 | TLR8 (0.40) | CRHR1KDM4EALDH1A1TLR8TP53 | |
| SCHEMBL1482411 | 0.84 | TP53 (0.46) | CRHR1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1577044 | 0.82 | CRHR1 (0.38) | CRHR1ADORA2B | |
| SCHEMBL1577515 | 0.82 | KMT2A (0.43) | CRHR1ALDH1A1TP53 | |
| SCHEMBL1577411 | 0.81 | CRHR1 (0.42) | CRHR1HPGDGAASMN1; SMN2 | |
| SCHEMBL1577206 | 0.80 | CCR2 (0.41) | — | |
| SCHEMBL1577251 | 0.80 | CRHR1 (0.41) | CRHR1HPGDGAASMN1; SMN2 | |
| SCHEMBL1577202 | 0.79 | ALOX5 (0.43) | CRHR1HPGDGAASMN1; SMN2 | |
| SCHEMBL1577493 | 0.77 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL1577420 | 0.76 | HTR2C (0.42) | CRHR1KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483247-A1 | NEW BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011039130-A1 | NEW BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-07 | — | — | WO | disclosed |