Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 17/20 | 0.74 |
| ▸ | TNKS2 | Q9H2K2 | 17/20 | 0.74 |
| ▸ | PARP1 | P09874 | 13/20 | 0.74 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.69 |
| ▸ | GUSB | P08236 | 2/20 | 0.62 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775530 | 0.85 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL1387251 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL7576663 | 0.82 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775574 | 0.81 | TNKS (0.54) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775356 | 0.77 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15840747 | 0.74 | PARP1 (0.68) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL30665826 | 0.71 | TNKS (0.75) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL2126968 | 0.71 | TNKS (0.59) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL7500358 | 0.71 | TNKS (0.60) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL6330691 | 0.70 | PARP1 (0.70) | TNKSTNKS2PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |