Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.54 |
| ▸ | WNT3A | P56704 | 2/20 | 0.54 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776205 | 0.83 | ADORA2A (0.55) | TNKSTNKS2PARP1MAPT | |
| SCHEMBL15775972 | 0.82 | TNKS (0.51) | TNKSTNKS2PARP1TRPV1RAB9A | |
| SCHEMBL15775287 | 0.82 | TNKS (0.51) | TNKSTNKS2PARP2PARP1NPY5R | |
| SCHEMBL3237120 | 0.80 | TRPV1 (0.56) | TNKSTNKS2WNT3ATRPV1NPY5R | |
| SCHEMBL15775354 | 0.79 | TNKS (0.62) | TNKSTNKS2WNT3APARP2PARP1 | |
| SCHEMBL15775723 | 0.78 | TNKS2 (0.65) | TNKSTNKS2WNT3APARP2PARP1 | |
| SCHEMBL15775277 | 0.75 | TNKS (0.65) | TNKSTNKS2WNT3APARP2PARP1 | |
| SCHEMBL15775430 | 0.75 | TNKS (0.65) | TNKSTNKS2WNT3APARP2PARP1 | |
| SCHEMBL5434565 | 0.74 | TNKS2 (0.67) | TNKSTNKS2WNT3APARP2PARP1 | |
| SCHEMBL10742407 | 0.74 | CCNB2 (0.51) | TNKSTNKS2WNT3APARP1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |