Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.51 |
| ▸ | PARP1 | P09874 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776205 | 0.86 | ADORA2A (0.55) | TNKSTNKS2PARP1ALDH1A1TSHR | |
| SCHEMBL15775287 | 0.85 | TNKS (0.51) | TNKSTNKS2PARP1ALDH1A1NPC1 | |
| SCHEMBL15775720 | 0.82 | TNKS (0.54) | TNKSTNKS2PARP1RAB9AMAPT | |
| SCHEMBL15775687 | 0.77 | TNKS (0.59) | TNKSTNKS2PARP1ALDH1A1NPC1 | |
| SCHEMBL15775973 | 0.77 | TNKS (0.62) | TNKSTNKS2PARP1RAB9AAURKA | |
| SCHEMBL3058184 | 0.76 | METAP2 (0.58) | PARP1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL15775324 | 0.75 | TNKS (0.61) | TNKSTNKS2PARP1 | |
| SCHEMBL15775256 | 0.73 | ACHE (0.49) | TNKSTNKS2PARP1ALDH1A1NPC1 | |
| SCHEMBL15775358 | 0.73 | AURKA (0.46) | TNKSTNKS2PARP1ALDH1A1NPC1 | |
| SCHEMBL3246330 | 0.73 | AURKA (0.53) | PARP1ALDH1A1AURKAADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |