Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15780892 | 0.84 | L3MBTL1 (0.39) | NPSR1L3MBTL1HPGDLMNAPOLB | |
| SCHEMBL15780898 | 0.79 | NPSR1 (0.44) | NPSR1L3MBTL1HPGDLMNAPOLB | |
| SCHEMBL2343551 | 0.78 | CYP2C19 (0.43) | NPSR1L3MBTL1HPGDLMNAPOLB | |
| SCHEMBL15780893 | 0.75 | EPHX1 (0.42) | LMNAALDH1A1KDM4EPIK3CAMTOR | |
| SCHEMBL15780901 | 0.72 | ALDH1A1 (0.46) | HPGDLMNAPOLBATMTDP1 | |
| SCHEMBL19623540 | 0.70 | PIK3CA (0.57) | NPSR1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL2339714 | 0.67 | HTR2C (0.58) | TDP1USP2 | |
| SCHEMBL2343194 | 0.66 | ALDH1A1 (0.47) | NPSR1L3MBTL1HPGDLMNAPOLB | |
| SCHEMBL24698533 | 0.66 | GBA1 (0.46) | L3MBTL1HPGDLMNAPOLBMAPK1 | |
| SCHEMBL2337911 | 0.66 | HTR2C (0.56) | NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163023-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163023-A1 | DIHYDROPYRROLO PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | NPSR1 2430/4885L3MBTL1 2742/4885HPGD 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.