Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569583 | 0.83 | GPR84 (0.38) | GABRA1GABRB2PRKCIALDH1A1HSD17B10 | |
| SCHEMBL519233 | 0.83 | ALDH1A1 (0.39) | GABRA1GABRB2KMT2AALDH1A1LMNA | |
| SCHEMBL24183230 | 0.81 | GABRA1 (0.32) | GABRA1GABRB2 | |
| SCHEMBL8182312 | 0.81 | CCNC (0.41) | GABRA1GABRB2 | |
| SCHEMBL31330091 | 0.78 | CNR2 (0.42) | CA12L3MBTL1KMT2AALDH1A1LMNA | |
| SCHEMBL15090763 | 0.76 | KDM4E (0.46) | CA12KMT2AALDH1A1LMNAHTT | |
| SCHEMBL20674242 | 0.76 | CDK8 (0.39) | CA12L3MBTL1KMT2ALMNAGAA | |
| SCHEMBL4676687 | 0.75 | KMT2A (0.39) | KMT2AALDH1A1LMNA | |
| SCHEMBL15782805 | 0.74 | CA12 (0.44) | HSD17B1CA12PRKCIL3MBTL1KMT2A | |
| SCHEMBL27814142 | 0.74 | HSP90AB1 (0.39) | L3MBTL1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107556255-A | A kind of organic amine modified melamine polyphosphate and preparation method thereof | 东华大学 | 2018-01-09 | — | — | CN | claimed |
| CN-107459492-A | A kind of organically-modified melamine polyphosphate and preparation method thereof | 东华大学 | 2017-12-12 | — | — | CN | claimed |
| US-10669244-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-06-02 | — | — | US | disclosed |
| CN-107892665-A | A kind of preparation method of N-ethyl-2-acetyl pyrrole | 山东吉田香料股份有限公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-107556255-A | A kind of organic amine modified melamine polyphosphate and preparation method thereof | 东华大学 | 2018-01-09 | — | — | CN | disclosed |
| CN-107459492-A | A kind of organically-modified melamine polyphosphate and preparation method thereof | 东华大学 | 2017-12-12 | — | — | CN | disclosed |
| EP-3138831-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | President and Fellows of Harvard College (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9365493-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-06-14 | — | — | US | disclosed |
| US-20140163238-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163238-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | HSD17B1 1662/4885GABRA1 3814/4885GABRB2 4152/4885 |
| US-10669244-B2 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | HSD17B1 1662/4885GABRA1 3814/4885GABRB2 4152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.