SCHEMBL158104

SCHEMBL158104

[c]1cc2[nH]ccnc-2n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17199 0.67
SCHEMBL20357190 0.67 NISCH (0.39)
Hydrochloric Acid SCHEMBL1935429 0.65 ALDH1A1 (0.39)
Hydrochloric Acid SCHEMBL28232772 0.65 ALDH1A1 (0.39)
SCHEMBL3088467 0.65 ALDH1A1 (0.39)
SCHEMBL87466 0.57 NISCH (0.54)
SCHEMBL27378333 0.57
SCHEMBL31657711 0.57
SCHEMBL434461 0.56 NISCH (0.42)
SCHEMBL442421 0.56 KDM4C (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 361 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3533797-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2023-12-20 EP disclosed
US-11174272-B2 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-11-16 US disclosed
US-20210206781-A1 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES TAKEDA PHARMACEUTICALS CO (JP) 2021-07-08 US disclosed
US-10717748-B2 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-07-21 US disclosed
US-10662156-B2 Guanidine derivative and medical use thereof TORAY INDUSTRIES, INC. (JP) 2020-05-26 US disclosed
US-20200157117-A1 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES TAKEDA PHARMACEUTICALS CO (JP) 2020-05-21 US disclosed
US-10550129-B2 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-02-04 US disclosed
EP-3533797-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2019-09-04 EP disclosed
EP-2982666-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2019-08-07 EP disclosed
US-20190233376-A1 GUANIDINE DERIVATIVE AND MEDICAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 2019-08-01 US disclosed
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 WO disclosed
US-20070037807-A1 Pyridine compounds as inhibitors of dipeptidyl peptidase IV TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-15 US disclosed
CN-1886376-A Pyridine compounds as dipeptidyl dipeptidase-IV inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2006-12-27 CN disclosed
WO-2006090915-A1 PYRIDYL ACETIC ACID COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-08-31 WO disclosed
US-6552058-B1 For therapy of diabetes or hyperlipidemia TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-04-22 US disclosed
US-6147099-A USEFUL AS ANTI-DIABETICS OR HYPOLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, INC. (JP) 2000-11-14 US disclosed
US-5972970-A COMPOUNDS SUCH AS 5-(3-(2-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL) ETHOXYL-5-PYRIDYL)PROPYL)-2,4-OXAZOLIDINEDIONE; ADMINISTERING TO TREAT A MAMMAL SUFFERING FROM DIABETES OR HYPERLIPIDEMIA TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-26 US disclosed
EP-0612743-B1 Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-10 EP disclosed
US-5665748-A ANTIDIABETIC, HYPOLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-09 US disclosed
EP-0612743-A1 Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-31 EP disclosed