Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13280285 | 0.86 | OPRK1 (0.42) | OPRK1YAP1 | |
| SCHEMBL13281830 | 0.85 | OPRK1 (0.41) | OPRK1YAP1CYP3A4CYP2D6CHEK1 | |
| SCHEMBL13280087 | 0.84 | ALDH1A1 (0.51) | CNR1MAPTALDH1A1TP53 | |
| SCHEMBL13280057 | 0.84 | RHOA (0.38) | YAP1CYP2D6CHEK1CHEK2CNR1 | |
| SCHEMBL13280494 | 0.84 | YAP1 (0.49) | OPRK1YAP1MEN1KMT2AALDH1A1 | |
| SCHEMBL13279855 | 0.84 | YAP1 (0.52) | OPRK1YAP1MEN1KMT2AALDH1A1 | |
| SCHEMBL13280731 | 0.83 | YAP1 (0.54) | OPRK1YAP1MEN1KMT2AALDH1A1 | |
| SCHEMBL15710527 | 0.83 | YAP1 (0.54) | OPRK1YAP1MEN1KMT2AALDH1A1 | |
| SCHEMBL15864933 | 0.81 | EZH2 (0.39) | OPRK1CYP2D6MEN1KMT2AHSD17B10 | |
| SCHEMBL18830119 | 0.81 | YAP1 (0.41) | OPRK1YAP1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022184-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2016-05-25 | — | — | EP | disclosed |
| EP-2935214-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2015010049-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2015-01-22 | — | — | WO | disclosed |
| WO-2014100646-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |