⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57641 | 0.82 | ALDH1A1 (0.41) | — | |
| SCHEMBL25172618 | 0.76 | KCNH2 (0.31) | — | |
| SCHEMBL3523639 | 0.76 | L3MBTL1 (0.38) | — | |
| SCHEMBL25185702 | 0.76 | CSNK2A1 (0.30) | — | |
| SCHEMBL1989766 | 0.76 | L3MBTL1 (0.34) | — | |
| SCHEMBL29242332 | 0.74 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL29160711 | 0.73 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL455316 | 0.73 | — | — | |
| SCHEMBL25172614 | 0.73 | KMT2A (0.34) | — | |
| SCHEMBL22676 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 531 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11795166-B2 | Pyrazolopyridine compounds and uses thereof | INCYTE CORPORATION (US) | 2023-10-24 | — | — | US | claimed |
| EP-4119558-A1 | PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF | Incyte Corporation (US) | 2023-01-18 | — | — | EP | claimed |
| CN-109923114-B | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2022-11-01 | — | — | CN | claimed |
| EP-3510032-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORP (US) | 2022-07-06 | — | — | EP | claimed |
| CN-112402385-B | 4-hydroxymethyl-1H-indole compound pharmaceutical preparation and preparation method thereof | 北京华氏开元医药科技有限公司 | 2022-04-01 | — | — | CN | claimed |
| CN-113874372-A | Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi | PI工业有限公司 | 2021-12-31 | — | — | CN | claimed |
| US-20210380581-A1 | PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-12-09 | — | — | US | claimed |
| CN-112194652-B | 4-hydroxymethyl-1H-indole compound, preparation method and application | 北京华氏开元医药科技有限公司 | 2021-03-05 | — | — | CN | claimed |
| CN-112402385-A | 4-hydroxymethyl-1H-indole compound pharmaceutical preparation and preparation method thereof | 北京华氏开元医药科技有限公司 | 2021-02-26 | — | — | CN | claimed |
| CN-112194652-A | 4-hydroxymethyl-1H-indole compound, preparation method and application | 北京华氏开元医药科技有限公司 | 2021-01-08 | — | — | CN | claimed |
| WO-2006077428-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-27 | — | — | WO | claimed |
| WO-2006077424-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-27 | — | — | WO | claimed |
| WO-2006077425-A1 | COMBINATIONS OF PYRAZOLE KINASE INHIBITORS AND FURTHER ANTITUMOR AGENTS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-27 | — | — | WO | claimed |
| EP-1651612-A1 | 3,4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASES (CDK) AND GLYCOGEN SYNTHASE KINASE-3 (GSK-3) MODULATORS | Astex Therapeutics Limited (GB) | 2006-05-03 | — | — | EP | claimed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | claimed |
| WO-2006008545-A2 | THIAZOLE AND ISOTHIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-01-26 | — | — | WO | claimed |
| WO-2005012256-A1 | 3, 4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASES (CDK) AND GLYCOGEN SYNTHASE KINASE-3 (GSK-3) MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | claimed |
| WO-2000015606-A1 | SUBSTITUTED N-ARYL-O-ALKYL-CARBAMATES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-03-23 | — | — | WO | claimed |
| EP-0091193-B1 | ANTIDIABETIC COMPOSITIONS | PFIZER INC. (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0091193-A2 | Antidiabetic compositions | PFIZER INC. (US) | 1983-10-12 | — | — | EP | claimed |