SCHEMBL15823470

SCHEMBL15823470

COc1cc(NC(=O)OCCCc2ccc(-c3ccccc3)c(NC(=O)O)c2)c(Cl)cc1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
LMNA P02545 2/20 0.37
TSHR P16473 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
CHRM3 P20309 3/20 0.35
ACHE P22303 2/20 0.35
KMT2A Q03164 1/20 0.34
POLB P06746 2/20 0.33
BCHE P06276 1/20 0.33
MMP2 P08253 2/20 0.33
EGFR P00533 2/20 0.33
KDR P35968 2/20 0.33
MMP3 P08254 1/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
RECQL P46063 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL97653 0.89 CHEK1 (0.42) ALDH1A1LMNATSHRL3MBTL1PDCD1
SCHEMBL100322 0.88 HPGD (0.44) ALDH1A1TSHRL3MBTL1PDCD1CD274
SCHEMBL15824060 0.87 ALDH1A1 (0.42) ALDH1A1LMNATSHRNPSR1L3MBTL1
SCHEMBL17259845 0.82 CHRM3 (0.46) CHRM3
SCHEMBL17259847 0.82 CHRM3 (0.46) CHRM3
SCHEMBL99117 0.82 CHEK1 (0.38) ALDH1A1NPSR1L3MBTL1CD274KMT2A
SCHEMBL15824440 0.82 CACNA1B (0.38) CHRM3
SCHEMBL15824442 0.82 CACNA1B (0.38) CHRM3
SCHEMBL15822677 0.81 ALDH1A1 (0.41) ALDH1A1LMNATSHRNPSR1L3MBTL1
SCHEMBL99659 0.80 POLB (0.40) ALDH1A1LMNATSHRNPSR1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2934594-B1 CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES . ALMIRALL SA (ES) 2019-09-04 EP disclosed
EP-2934594-A1 NEW CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITY Almirall, S.A. (ES) 2015-10-28 EP disclosed
WO-2014095920-A1 NEW CYCLOHEXYL AND QUINUCLIDINYL CARBAMATE DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITY ALMIRALL, S.A. (ES) 2014-06-26 WO disclosed