Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291536 | 0.91 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3MAP4K1PIM1 | |
| Tert-Butyl Formate SCHEMBL27844205 | 0.86 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3MAP4K1PIM1 | |
| SCHEMBL5158426 | 0.86 | HTR6 (0.43) | SLC6A2PIM1PIM3CHRNB2CHRNA4 | |
| SCHEMBL255543 | 0.83 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3MAP4K1PIM1 | |
| SCHEMBL255556 | 0.83 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3MAP4K1PIM1 | |
| SCHEMBL21414395 | 0.80 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3MAP4K1PIM1 | |
| SCHEMBL3594508 | 0.80 | CHRNB2 (0.56) | SLC6A2SLC6A4SLC6A3MAP4K1WEE1 | |
| SCHEMBL15341607 | 0.80 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3MAP4K1PIM1 | |
| SCHEMBL18291708 | 0.79 | SMN1; SMN2 (0.42) | PIM1PIM3CHRNB2CHRNA4CDK4 | |
| Hydrochloric Acid SCHEMBL1583990 | 0.79 | CHRNB2 (0.54) | SLC6A2SLC6A4SLC6A3MAP4K1WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016194831-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 帝人ファーマ株式会社 | 2016-12-08 | — | — | WO | disclosed |
| WO-2015038417-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | disclosed |
| EP-2611790-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Gilead Connecticut, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031004-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| EP-1742634-A1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAgen, Incorporated (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005099711-A1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |