Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158236 | 0.86 | SLC6A2 (0.44) | HTR6PIM1PIM3CHRNB2CHRNA4 | |
| SCHEMBL20037996 | 0.84 | HTR6 (0.42) | HTR6PIM1PIM3CHRNB2CHRNA4 | |
| SCHEMBL18291654 | 0.84 | PIM1 (0.43) | HTR6PIM1PIM3CHRNB2CHRNA4 | |
| SCHEMBL1269266 | 0.81 | ALDH1A1 (0.51) | HTR6AKR1C3ALDH1A1 | |
| SCHEMBL31035634 | 0.81 | ALDH1A1 (0.51) | HTR6AKR1C3ALDH1A1 | |
| SCHEMBL20249254 | 0.80 | HTR6 (0.40) | HTR6PIM1PIM3CHRNB2CHRNA4 | |
| SCHEMBL20203473 | 0.80 | HTR6 (0.40) | HTR6PIM1PIM3CHRNB2CHRNA4 | |
| SCHEMBL2343208 | 0.80 | AKR1C3 (0.49) | HTR6AKR1C3ALDH1A1 | |
| SCHEMBL12279805 | 0.78 | AKR1C3 (0.50) | HTR6AKR1C3ALDH1A1 | |
| SCHEMBL18291536 | 0.78 | SLC6A2 (0.56) | HTR6PIM1PIM3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740155-A1 | POLYCYLIC THIAZOLES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005099673-A1 | POLYCYLIC THIAZOLES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |