Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nizatidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | ATP4A | P20648 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | ATP4B | P51164 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nizatidine SCHEMBL9369530 | 1.00 | ACHE (0.80) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL9465388 | 0.91 | ACHE (0.74) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL9241933 | 0.90 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL769 | 0.90 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL770 | 0.90 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL13575816 | 0.90 | ACHE (1.00) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL158261 | 0.89 | ACHE (0.88) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL5041217 | 0.89 | ACHE (0.98) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL28723397 | 0.89 | ACHE (0.98) | ACHEMEN1SLC22A1ABCB11LMNA | |
| Nizatidine SCHEMBL6239553 | 0.88 | ACHE (0.96) | ACHEMEN1SLC22A1ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367484-B1 | Carboxylic acid derivates | GLAXO GROUP LTD (GB) | 1994-02-16 | — | — | EP | claimed |