Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076041 | 0.70 | ACHE (0.57) | ACHEMAPK8CDC7CCR4PTPN11 | |
| SCHEMBL32679532 | 0.70 | CCNE1 (0.49) | ACHECCNE1CDK2EGFR | |
| SCHEMBL2073001 | 0.69 | ACHE (0.59) | ACHEMAPK8CDC7PTPN11L3MBTL1 | |
| SCHEMBL27810118 | 0.68 | KDM4E (0.53) | HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL2075359 | 0.68 | ACHE (0.57) | ACHEPTPN11EGFRL3MBTL1 | |
| SCHEMBL12783965 | 0.67 | PAK4 (0.74) | — | |
| SCHEMBL27830611 | 0.65 | ADRB1 (0.59) | HRH3L3MBTL3L3MBTL1 | |
| SCHEMBL2075454 | 0.65 | ACHE (0.59) | ACHEMAPK8CDC7HRH3PTPN11 | |
| SCHEMBL15827614 | 0.65 | ACHE (0.46) | ACHECDK2 | |
| SCHEMBL2074791 | 0.64 | ACHE (0.55) | ACHECCR4PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464641-B1 | PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS | VERTEX PHARMA (US) | 2014-06-25 | — | — | EP | disclosed |