Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1583704 | 0.88 | ACMSD (0.34) | KDM4EMC4RLDHAPTGS2PKM | |
| SCHEMBL3793277 | 0.82 | NOTUM (0.41) | NOTUMKDM4ENR4A2LDHACFTR | |
| SCHEMBL3074208 | 0.82 | CFTR (0.48) | NOTUMKDM4ENR4A2MC4RLDHA | |
| SCHEMBL3058542 | 0.81 | NOTUM (0.39) | NOTUMKDM4ELDHACFTRMRGPRX4 | |
| SCHEMBL1583640 | 0.80 | NOTUM (0.41) | NOTUMKDM4ELDHACFTRPKM | |
| SCHEMBL1583743 | 0.80 | CFTR (0.53) | NOTUMKDM4ENR4A2AXLLDHA | |
| SCHEMBL7490627 | 0.80 | PKM (0.45) | KDM4EPKMALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1583159 | 0.79 | NOTUM (0.40) | NOTUMKDM4ELDHACFTRPKM | |
| SCHEMBL1584276 | 0.79 | NOTUM (0.38) | NOTUMKDM4ELDHACFTRMRGPRX4 | |
| SCHEMBL3691065 | 0.79 | CFTR (0.40) | NOTUMKDM4ELDHACFTRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041713-A2 | PIPERAZINYL ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-07 | — | — | WO | disclosed |