Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 10/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NRAS | P01111 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15829874 | 0.87 | FLT3 (0.37) | HRH3FLT3ESR1NRASIRAK4 | |
| SCHEMBL15829873 | 0.84 | HRH3 (0.39) | HRH3FLT3NPSR1NRASIRAK4 | |
| SCHEMBL17300794 | 0.81 | NPSR1 (0.37) | HRH3FLT3NPSR1NRASIRAK4 | |
| SCHEMBL15830004 | 0.76 | HRH3 (0.36) | HRH3FLT3ESR1HRH4HRH2 | |
| SCHEMBL15834821 | 0.75 | MALT1 (0.38) | HRH3FLT3HRH4HRH2 | |
| SCHEMBL17072661 | 0.75 | HRH4 (0.46) | HRH3FLT3IRAK4HRH4HRH2 | |
| SCHEMBL15834094 | 0.72 | ROCK1 (0.44) | HRH4 | |
| SCHEMBL15834078 | 0.70 | RXRA (0.32) | HRH3ESR1 | |
| SCHEMBL21140418 | 0.70 | FLT3 (0.45) | HRH3FLT3HRH4 | |
| SCHEMBL19633544 | 0.70 | HRH3 (0.35) | HRH3FLT3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100734-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |