Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834821 | 0.87 | MALT1 (0.38) | HRH3HRH4HRH2FLT3 | |
| SCHEMBL17383741 | 0.83 | ESR1 (0.31) | HRH3ESR1 | |
| SCHEMBL15833955 | 0.81 | HRH3 (0.39) | HRH3HRH4HRH2FLT3 | |
| SCHEMBL17300826 | 0.81 | HRH3 (0.39) | HRH3HRH4HRH2FLT3 | |
| SCHEMBL15829874 | 0.77 | FLT3 (0.37) | HRH3FLT3CXCR4ESR1 | |
| SCHEMBL15834573 | 0.77 | CCNT1 (0.45) | HRH3HRH4HRH2FLT3 | |
| SCHEMBL15834730 | 0.76 | HRH3 (0.38) | HRH3HRH4HRH2FLT3ESR1 | |
| SCHEMBL12341383 | 0.76 | NOS3 (0.45) | HRH3ESR1 | |
| SCHEMBL17300798 | 0.74 | HRH3 (0.36) | HRH3HRH4HRH2FLT3 | |
| SCHEMBL15834094 | 0.73 | ROCK1 (0.44) | HRH4CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015200677-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2014100719-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |