Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | IL1B | P01584 | 6/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830004 | 0.87 | HRH3 (0.36) | HRH3FLT3HRH4HRH2 | |
| SCHEMBL17303779 | 0.81 | MALT1 (0.41) | MALT1HRH3IL1BFLT3 | |
| SCHEMBL17300777 | 0.79 | MALT1 (0.39) | MALT1HRH3IL1BFLT3MAPK1 | |
| SCHEMBL15830314 | 0.78 | CCNT1 (0.44) | MALT1HRH3IL1BFLT3MAPK1 | |
| SCHEMBL15829874 | 0.76 | FLT3 (0.37) | HRH3FLT3 | |
| SCHEMBL15834730 | 0.75 | HRH3 (0.38) | HRH3FLT3HRH4HRH2 | |
| SCHEMBL15390274 | 0.73 | MAPK1 (0.50) | MALT1HRH3FLT3MAPK1HRH4 | |
| SCHEMBL15834094 | 0.72 | ROCK1 (0.44) | HRH4 | |
| SCHEMBL17072661 | 0.72 | HRH4 (0.46) | HRH3FLT3HRH4HRH2 | |
| SCHEMBL17383741 | 0.70 | ESR1 (0.31) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |
| WO-2014100734-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |