Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830004 | 0.83 | HRH3 (0.36) | ESR1HRH3 | |
| SCHEMBL17300821 | 0.81 | HMGCR (0.33) | CCNT1CDK9 | |
| SCHEMBL17303787 | 0.81 | KCNN2 (0.35) | CCNT1CDK9 | |
| SCHEMBL19957822 | 0.81 | ESR1 (0.33) | ESR1CCNT1CDK9HRH3 | |
| SCHEMBL15833954 | 0.77 | CCNT1 (0.46) | CCNT1CDK9HRH3 | |
| SCHEMBL21064102 | 0.77 | CCNT1 (0.38) | ESR1CCNT1CDK9HRH3 | |
| SCHEMBL15834078 | 0.77 | RXRA (0.32) | ESR1CCNT1CDK9HRH3 | |
| SCHEMBL19957555 | 0.77 | CCNT1 (0.33) | ESR1CCNT1CDK9HRH3 | |
| SCHEMBL17300764 | 0.74 | CCNT1 (0.30) | CCNT1CDK9 | |
| SCHEMBL17306652 | 0.74 | PTGS2 (0.31) | ESR1CCNT1CDK9HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015200677-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |