Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.43 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053665 | 0.91 | MAPT (0.51) | MAPTTDP1KDM4EATML3MBTL1 | |
| SCHEMBL12643655 | 0.91 | MAPT (0.51) | MAPTTDP1KDM4EATML3MBTL1 | |
| SCHEMBL14576371 | 0.91 | MAPT (0.51) | MAPTTDP1KDM4EATML3MBTL1 | |
| SCHEMBL15832199 | 0.87 | ATM (0.57) | MAPTATML3MBTL1NPC1RAB9A | |
| SCHEMBL15834851 | 0.87 | PTPN1 (0.52) | PSMB1PSMB9PSMB5PSMB10PSMB2 | |
| SCHEMBL15832201 | 0.86 | PPID (0.52) | MAPTATML3MBTL1NPC1RAB9A | |
| SCHEMBL12643860 | 0.86 | MAPT (0.56) | MAPTTDP1KDM4EATML3MBTL1 | |
| SCHEMBL15834853 | 0.80 | MAPT (0.53) | MAPTTDP1KDM4EATML3MBTL1 | |
| SCHEMBL14644454 | 0.78 | SCN9A (0.47) | PPARGPTPN1SCN9A | |
| SCHEMBL15832202 | 0.78 | LMNA (0.48) | L3MBTL1PPARGLTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179687-A1 | New Inhibitors of Cyclophilins and Uses Thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179687-A1 | New Inhibitors of Cyclophilins and Uses Thereof | FKBP3, FKBP4, FKBP5 | MAPT 3890/4885TDP1 4285/4885KDM4E 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.