Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRK3 | P35626 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29359016 | 0.80 | LMNA (0.55) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL27926709 | 0.80 | LMNA (0.55) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL19597584 | 0.80 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL10532918 | 0.77 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL370672 | 0.76 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL29582472 | 0.76 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL6491400 | 0.75 | CYP1A2 (0.50) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL6491397 | 0.75 | CYP1A2 (0.50) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL6130400 | 0.74 | LMNA (0.62) | SMN1; SMN2CYP2D6MEN1KMT2AALDH1A1 | |
| SCHEMBL8787698 | 0.74 | CYP2D6 (0.50) | NPC1RAB9ASMN1; SMN2TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100764-A2 | METHODS OF INHIBITING PRMT5 | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |