Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17300438 | 0.93 | ALDH1A1 (0.42) | NPC1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL22417572 | 0.92 | ALDH1A1 (0.41) | NPC1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL15837767 | 0.90 | NPC1 (0.44) | NPC1ALDH1A1RAB9A | |
| SCHEMBL15837685 | 0.90 | NPC1 (0.42) | NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15837770 | 0.89 | PSEN1 (0.46) | NPC1ALDH1A1KDM4E | |
| SCHEMBL15837704 | 0.89 | EPHX2 (0.44) | NPC1 | |
| SCHEMBL15837678 | 0.89 | NPC1 (0.53) | NPC1 | |
| SCHEMBL15837687 | 0.89 | ALDH1A1 (0.43) | NPC1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL15837683 | 0.89 | NPC1 (0.41) | NPC1ALDH1A1KDM4E | |
| SCHEMBL17300444 | 0.88 | PSEN1 (0.42) | NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935281-B1 | SPIROISOXAZOLINE COMPOUNDS HAVING AN ACTIVITY POTENTIATING THE ACTIVITY OF AN ANTIBIOTIC | UNIVERSITÉ DE DROIT ET DE LA SANTÉ DE LILLE 2 (FR) | 2020-09-09 | — | — | EP | disclosed |
| US-10174050-B2 | Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2019-01-08 | — | — | US | disclosed |
| US-20150344498-A1 | Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2015-12-03 | — | — | US | disclosed |
| US-20150344498-A1 | Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2015-12-03 | — | — | US | disclosed |
| WO-2014096369-A1 | SPIROISOXAZOLINE COMPOUNDS HAVING AN ACTIVITY POTENTIATING THE ACTIVITY OF AN ANTIBIOTIC | UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2 (FR) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344498-A1 | Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic | NPPA, CFTR, TCF7 | NPC1 143/4885ALDH1A1 1148/4885LMNA 528/4885 |
| US-10174050-B2 | Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic | NPPA, CFTR, TCF7 | NPC1 143/4885ALDH1A1 1148/4885LMNA 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.