Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 6/20 | 0.60 |
| ▸ | CA9 | Q16790 | 6/20 | 0.60 |
| ▸ | CA1 | P00915 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15838841 | 0.90 | ALDH1A1 (0.66) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL15838840 | 0.84 | CA12 (0.58) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL21844936 | 0.83 | ALDH1A1 (0.63) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL17947763 | 0.80 | CA9 (0.90) | MAPTGAANPSR1MEN1KMT2A | |
| SCHEMBL15962516 | 0.80 | MEN1 (0.70) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL15953012 | 0.79 | CA12 (0.84) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL14485108 | 0.79 | SMN1; SMN2 (1.00) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL14485232 | 0.79 | MAPT (0.82) | MAPTALDH1A1TSHRMAPK1MEN1 | |
| SCHEMBL19631199 | 0.77 | SMN1; SMN2 (0.73) | MAPTALDH1A1TSHRMAPK1GAA | |
| SCHEMBL29372795 | 0.77 | CA9 (0.65) | MAPTALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890117-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890117-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-9533947-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2017-01-03 | — | — | US | disclosed |
| US-9371277-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-22 | — | — | US | disclosed |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-22 | — | — | US | disclosed |
| US-20140234939-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2014100833-A1 | BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE | NORTHWESTERN UNIVERSITY (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | MAPT 248/4885ALDH1A1 929/4885TSHR 3406/4885 |
| US-20140234939-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | MAPT 248/4885ALDH1A1 929/4885TSHR 3406/4885 |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | MAPT 248/4885ALDH1A1 929/4885TSHR 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.