Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616379 | 0.75 | MAPK1 (0.37) | HSD11B1EPHX2CYP2C9L3MBTL1 | |
| Carbamic Acid SCHEMBL15015728 | 0.73 | TSHR (0.46) | HSD11B1TSHREPHX2KDM4ENPC1 | |
| Acetic Acid SCHEMBL28029262 | 0.73 | TSHR (0.46) | HSD11B1TSHREPHX2KDM4ENPC1 | |
| SCHEMBL15840887 | 0.72 | ALDH1A1 (0.36) | HSD11B1MEN1KMT2A | |
| SCHEMBL5249363 | 0.72 | TSHR (0.44) | HSD11B1TSHREPHX2KDM4ENPC1 | |
| Adamantan-2-Ol SCHEMBL1150618 | 0.71 | CYP2C9 (0.62) | HSD11B1TSHREPHX2CYP2C9 | |
| SCHEMBL20878810 | 0.71 | HSD11B1 (0.34) | HSD11B1MEN1KMT2A | |
| SCHEMBL10285140 | 0.71 | TSHR (0.40) | TSHREPHX2KDM4ENPC1 | |
| SCHEMBL4721541 | 0.71 | TSHR (0.40) | TSHREPHX2KDM4ENPC1 | |
| SCHEMBL71132 | 0.71 | TSHR (0.40) | TSHREPHX2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150349277-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-20150349277-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-20150333280-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-20150333280-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| WO-2014094961-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014094960-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150333280-A1 | Metal Complexes | SOD1, AP1M1, AP3M1 | HSD11B1 4370/4885TSHR 4496/4885EPHX2 3537/4885 |
| US-20150349277-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | HSD11B1 4370/4885TSHR 4496/4885EPHX2 3537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.