Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754308 | 0.86 | AKR1C3 (0.58) | KMT2ANPC1MEN1ALDH1A1HTT | |
| SCHEMBL4543721 | 0.84 | AKR1C3 (0.69) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL29530541 | 0.84 | AKR1C3 (0.69) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| Benzene SCHEMBL28318261 | 0.84 | AKR1C3 (0.61) | KMT2ANPC1MEN1MAPK14ALDH1A1 | |
| SCHEMBL236 | 0.84 | AKR1C3 (0.61) | KMT2APOLBRAB9ANPC1MAPK13 | |
| Benzene SCHEMBL27600962 | 0.84 | AKR1C3 (0.61) | KMT2APOLBRAB9ANPC1MAPK13 | |
| SCHEMBL9451511 | 0.84 | AKR1C3 (0.61) | KMT2APOLBRAB9ANPC1MAPK13 | |
| SCHEMBL29402362 | 0.84 | AKR1C3 (0.61) | KMT2APOLBRAB9ANPC1MAPK13 | |
| SCHEMBL4438678 | 0.83 | MAPK14 (0.60) | KMT2APOLBRAB9ANPC1MEN1 | |
| SCHEMBL1630013 | 0.82 | LIG1 (0.66) | KMT2ARAB9ANPC1MEN1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116375568-B | Method for reacting unactivated ketone and diiodobenzene | 苏州大学 | 2024-12-17 | — | — | CN | disclosed |
| CN-116375568-A | Method for reacting unactivated ketone and diiodobenzene | 苏州大学 | 2023-07-04 | — | — | CN | disclosed |
| EP-2486005-B1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-06-18 | — | — | EP | disclosed |
| US-8288404-B2 | Pyrrolidine GPR40 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-10-16 | — | — | US | disclosed |
| EP-2486005-A1 | PYRROLIDINE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044073-A1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20110082165-A1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082165-A1 | PYRROLIDINE GPR40 MODULATORS | GPR55, GPR65, GPR27 | KMT2A 3563/4885POLB 4127/4885RAB9A 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.