SCHEMBL1584484

SCHEMBL1584484

C[SiH](C)OCCCCOCC1CO1

nearest known ligand 0.69

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.69
ALDH1A1 P00352 6/20 0.61
TDP1 Q9NUW8 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.60
MAPK1 P28482 1/20 0.42
TP53 P04637 1/20 0.31
CYP3A4 P08684 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
GLA P06280 1/20 0.30
PDK1 Q15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL465558 0.98 TSHR (0.67) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL7193941 0.96 TSHR (0.63) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL4805738 0.93 TSHR (0.64) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL7194633 0.88 TSHR (0.56) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL13974192 0.83 TSHR (1.00) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL17549553 0.83 TSHR (1.00) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL17549552 0.83 TSHR (1.00) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL17549551 0.83 TSHR (1.00) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL21272 0.83 TSHR (1.00) TSHRALDH1A1TDP1SMN1; SMN2MAPK1
SCHEMBL3843910 0.81 TSHR (0.64) TSHRALDH1A1TDP1SMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214382-A1 PIGMENTED COATINGS FOR CERAMIC SUBSTRATES PPG Industries Ohio, Inc. (US) 2002-06-19 EP claimed
US-6214414-B1 HEATING TO CERAMIC SUBSTRATE HAVING SEQUENCE OF COATINGS OF PIGMENTED COATING TO CROSSLINK ALL OF PIGMENTED COATING OF SEQUENCE AND TO ADHERE SEQUENCE TO THE CERAMIC SUBSTRATE PPG INDUSTRIES OHIO, INC. 2001-04-10 US claimed
WO-2001007528-A1 PIGMENTED COATINGS FOR CERAMIC SUBSTRATES PPG INDUSTRIES OHIO, INC. (US) 2001-02-01 WO claimed
WO-2001007376-A1 METHOD FOR FORMING A SEQUENCE OF CROSSLINKED PIGMENTED COATINGS ON CERAMIC SUBSTRATES PPG INDUSTRIES OHIO, INC. (US) 2001-02-01 WO claimed
US-5674941-A CURABLE PROTECTIVE COATING FOR OPTICAL ARTICLES COMPRISING AN AMINE-CONTAINING SILANE AND AN ACRYLIC COPOLYMER HAVING PENDANT HYDROXY, EPOXY, AMINO AND/OR SILANE GROUPS; ANTIFOGGING AGENTS; ADHESION TO POLYCARBONATES; NONABRASIVE LUCKY LIMITED (KR) 1997-10-07 US claimed
US-20240158904-A1 UNDERCOAT AGENT COMPOSITION FOR LAYERING INORGANIC MATERIAL LAYER, CURED PRODUCT THEREOF AND PRODUCTION METHOD THEREOF TOAGOSEI CO., LTD. (JP) 2024-05-16 US disclosed
EP-4289618-A1 UNDERCOAT AGENT COMPOSITION FOR INORGANIC SUBSTANCE LAYER LAMINATION, CURED PRODUCT THEREOF, AND METHOD FOR PRODUCING SAME Toagosei Co., Ltd. (JP) 2023-12-13 EP disclosed
EP-4269516-A1 COMPOSITION FOR HYBRID POLYMERS HAVING BARRIER FUNCTION Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2023-11-01 EP disclosed
WO-2023171514-A1 LAMINATE AND PACKAGING MATERIAL DIC株式会社 2023-09-14 WO disclosed
US-11738091-B2 Method for terminating cancer cells with an azole-based compound IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2023-08-29 US disclosed
US-20230087061-A1 METHOD FOR TERMINATING CANCER CELLS WITH AN AZOLE-BASED COMPOUND IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2023-03-23 US disclosed
US-11564994-B2 Method for making a conjugate azole-based surface modified silicon dioxide nanoparticle IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY (SA) 2023-01-31 US disclosed
US-6039896-A RESINS, ORGANIC PEROXIDE, THERMOPLASTIC ELASTOMERS AND PHOSPHORIC ESTERS SUMITOMO BAKELITE CO., LTD. (JP) 2000-03-21 US disclosed
US-5877232-A WEAR RESISTANCE; DIMENSIONAL STABILITY; SHRINKAGE INHIBITION THE PROCTER & GAMBLE COMPANY (US) 1999-03-02 US disclosed
US-5756767-A Hydrolyzable and polyhmerizable silanes WOLTER HERBERT (DE) 1998-05-26 US disclosed
US-5674941-A CURABLE PROTECTIVE COATING FOR OPTICAL ARTICLES COMPRISING AN AMINE-CONTAINING SILANE AND AN ACRYLIC COPOLYMER HAVING PENDANT HYDROXY, EPOXY, AMINO AND/OR SILANE GROUPS; ANTIFOGGING AGENTS; ADHESION TO POLYCARBONATES; NONABRASIVE LUCKY LIMITED (KR) 1997-10-07 US disclosed
EP-0643752-A1 RESINOUS DENTAL COMPOSITION BASED ON POLYMERISABLE POLYSILOXANES THE PROCTER & GAMBLE COMPANY (US) 1995-03-22 EP disclosed
EP-0643752-A4 RESINOUS DENTAL COMPOSITION BASED ON POLYMERISABLE POLYSILOXANES. PROCTER & GAMBLE (US) 1994-06-03 EP disclosed
WO-1993007230-A1 RESINOUS DENTAL COMPOSITION BASED ON POLYMERISABLE POLYSILOXANES THE PROCTER & GAMBLE COMPANY (US) 1993-04-15 WO disclosed
US-4642266-A SCRATCH RESISTANCE AND WEATHERABILITY NIPPON SHEET GLASS CO., LTD. (JP) 1987-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11564994-B2 Method for making a conjugate azole-based surface modified silicon dioxide nanoparticle APC, AS3MT, SI TSHR 189/4885ALDH1A1 2798/4885TDP1 3373/4885
US-11738091-B2 Method for terminating cancer cells with an azole-based compound APC, CCNI, TTI1 TSHR 307/4885ALDH1A1 2408/4885TDP1 2794/4885
US-20230087061-A1 METHOD FOR TERMINATING CANCER CELLS WITH AN AZOLE-BASED COMPOUND APC, CCNI, TTI1 TSHR 307/4885ALDH1A1 2408/4885TDP1 2794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.