Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15850932 | 0.90 | PRPS1 (0.38) | GRIN2BALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2798622 | 0.87 | ALDH1A1 (0.43) | GRIN2BALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL19212760 | 0.78 | GRIN2B (0.47) | KCNH2GRIN2BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4136787 | 0.77 | KCNH2 (0.42) | KCNH2GRIN2BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL15850934 | 0.76 | ALDH1A1 (0.39) | KCNH2GRIN2BALDH1A1HPGDKDM4E | |
| SCHEMBL10285242 | 0.76 | GRIN2B (0.57) | GRIN2BALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL14313795 | 0.76 | CYP11B1 (0.48) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL29489040 | 0.76 | CYP11B1 (0.48) | ALDH1A1HPGDKDM4EHSD17B10USP2 | |
| SCHEMBL4776915 | 0.75 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL3859045 | 0.75 | ALDH1A1 (0.39) | GRIN2BALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952010-B2 | Amino group-containing pyrrolidinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8952010-B2 | Amino group-containing pyrrolidinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-03 | — | — | US | disclosed |
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | AR, RCC2, NR3C2 | KCNH2 2218/4885GRIN2B 62/4885ALDH1A1 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.