SCHEMBL1585587

SCHEMBL1585587

CCCO[SiH](CC(C)CC)OCCC

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2772585 0.82
SCHEMBL6086890 0.82
SCHEMBL4999906 0.80
SCHEMBL2771134 0.80 HSD17B10 (0.32) HSD17B10
SCHEMBL29201569 0.76 HSD17B10 (0.30) HSD17B10
SCHEMBL29201660 0.76 HSD17B10 (0.30) HSD17B10
SCHEMBL29201590 0.74
SCHEMBL3623231 0.74
SCHEMBL1069124 0.74
SCHEMBL28998035 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070087025-A1 Reiteratively layered medical devices and method of preparing same FITZHUGH ANTHONY 2007-04-19 US claimed
EP-1436018-A1 NITRIC OXIDE-RELEASING COATED MEDICAL DEVICES AND METHOD OF PREPARING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2004-07-14 EP claimed
WO-2003026717-A1 NITRIC OXIDE-RELEASING COATED MEDICAL DEVICES AND METHOD OF PREPARING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2003-04-03 WO claimed
US-9537052-B2 Coated phosphors and light emitting devices including the same CREE, INC. (US) 2017-01-03 US disclosed
EP-2714840-B1 COATED PHOSPHORS AND LIGHT EMITTING DEVICES INCLUDING THE SAME CREE INC (US) 2016-04-13 EP disclosed
US-9187501-B2 Nitric oxide-releasing nanorods and their methods of use THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2015-11-17 US disclosed
US-8981139-B2 Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2015-03-17 US disclosed
US-20140217326-A1 COATED PHOSPHORS AND LIGHT EMITTING DEVICES INCLUDING THE SAME CREE, INC. (US) 2014-08-07 US disclosed
US-8729790-B2 Coated phosphors and light emitting devices including the same CREE, INC. (US) 2014-05-20 US disclosed
US-20140134321-A1 NITRIC OXIDE-RELEASING COATINGS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2014-05-15 US disclosed
US-20140065200-A1 NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2014-03-06 US disclosed
WO-2011047013-A1 NITRIC OXIDE-RELEASING COATINGS NOVAN, INC. (US) 2011-04-21 WO disclosed
US-20110086234-A1 NITRIC OXIDE-RELEASING COATINGS NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR 2011-04-14 US disclosed
US-20070087025-A1 Reiteratively layered medical devices and method of preparing same FITZHUGH ANTHONY 2007-04-19 US disclosed
US-20070014828-A1 Cross-linked nitric oxide-releasing polyamine coated substrates, compositions comprising same and method of making same GOVERNMENT OF THE USA, REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2007-01-18 US disclosed
EP-1545798-A4 CROSS-LINKED NITRIC OXIDE-RELEASING POLYAMINE COATED SUBSTRATES, COMPOSITIONS COMPRISING SAME AND METHOD OF MAKING SAME US GOV HEALTH & HUMAN SERV (US) 2006-06-14 EP disclosed
EP-1545798-A1 CROSS-LINKED NITRIC OXIDE-RELEASING POLYAMINE COATED SUBSTRATES, COMPOSITIONS COMPRISING SAME AND METHOD OF MAKING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2005-06-29 EP disclosed
EP-1436018-A1 NITRIC OXIDE-RELEASING COATED MEDICAL DEVICES AND METHOD OF PREPARING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2004-07-14 EP disclosed
WO-2004012874-A1 CROSS-LINKED NITRIC OXIDE-RELEASING POLYAMINE COATED SUBSTRATES, COMPOSITIONS COMPRISING SAME AND METHOD OF MAKING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2004-02-12 WO disclosed
WO-2003026717-A1 NITRIC OXIDE-RELEASING COATED MEDICAL DEVICES AND METHOD OF PREPARING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2003-04-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070087025-A1 Reiteratively layered medical devices and method of preparing same NOS2, NOS1, NOS3 HSD17B10 2643/4885
US-20140065200-A1 NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE NOS2, NOS1, NOS3 HSD17B10 3796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.