Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7925119 | 0.81 | TAAR1 (0.50) | NPC1RAB9ATDP1TAAR1MEN1 | |
| SCHEMBL4607534 | 0.78 | ALDH1A1 (0.43) | NPC1RAB9ATSHRALDH1A1TP53 | |
| SCHEMBL22591638 | 0.78 | GFER (0.50) | TSHRTDP1GFERALDH1A1CYP3A4 | |
| SCHEMBL20226500 | 0.77 | TDP1 (0.41) | TSHRTDP1GFERALDH1A1CYP3A4 | |
| SCHEMBL15866011 | 0.75 | TSHR (0.46) | ITGB1ITGA5NPC1RAB9ATSHR | |
| SCHEMBL8089217 | 0.75 | TDP1 (0.42) | NPC1RAB9ATSHRTDP1GFER | |
| SCHEMBL20226533 | 0.74 | MAPT (0.46) | TSHRTDP1GFERALDH1A1CYP3A4 | |
| SCHEMBL3050047 | 0.74 | GRIA4 (0.41) | TDP1ALDH1A1TAAR1 | |
| SCHEMBL15134804 | 0.74 | NPC1 (0.41) | ITGB1ITGA5NPC1RAB9AITGB3 | |
| SCHEMBL15134799 | 0.74 | CYSLTR2 (0.47) | ITGB1ITGA5NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772542-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-07-08 | — | — | US | disclosed |