Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19407026 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KCNH2TMEM97NPC1RAB9A | |
| SCHEMBL11611907 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KCNH2TMEM97NPC1RAB9A | |
| SCHEMBL15865878 | 0.78 | ITGB1 (0.36) | ALDH1A1TP53TSHRNPC1RAB9A | |
| SCHEMBL7925119 | 0.78 | TAAR1 (0.50) | NPC1RAB9AMEN1KMT2ATAAR1 | |
| SCHEMBL28185303 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KCNH2TMEM97NPC1RAB9A | |
| SCHEMBL4608415 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KCNH2TMEM97NPC1RAB9A | |
| SCHEMBL13971048 | 0.76 | FFAR1 (0.50) | PPARGPPARAEPHX2SLC6A9L3MBTL1 | |
| SCHEMBL25215174 | 0.76 | TP53 (0.71) | ALDH1A1TP53TSHRKCNH2TMEM97 | |
| SCHEMBL25252393 | 0.76 | TP53 (0.71) | ALDH1A1TP53TSHRKCNH2TMEM97 | |
| SCHEMBL16379333 | 0.76 | TP53 (0.71) | ALDH1A1TP53TSHRKCNH2TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948603-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054739-A1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |