Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.43 |
| ▸ | IL2 | P60568 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15868154 | 0.86 | FAAH (0.43) | BRD4KDM4EIL2SMN1; SMN2 | |
| SCHEMBL15861810 | 0.81 | IL2 (0.54) | BRD4KDM4EIL2P2RX7SMN1; SMN2 | |
| SCHEMBL15868165 | 0.80 | PPARG (0.43) | KDM4EALDH1A1GAAPOLBAPOBEC3A | |
| SCHEMBL15861739 | 0.79 | IL2 (0.46) | BRD4KDM4EIL2P2RX7SMN1; SMN2 | |
| SCHEMBL15868125 | 0.77 | PTGDR2 (0.42) | KDM4EALDH1A1GAAPOLBAPOBEC3A | |
| SCHEMBL15884070 | 0.77 | BRD4 (0.41) | BRD4IL2CCNCCDK8KDM4C | |
| SCHEMBL17319157 | 0.75 | MMP2 (0.43) | BRD4POLBTDP1P2RX7 | |
| SCHEMBL15869831 | 0.74 | SMN1; SMN2 (0.47) | ALDH1A1L3MBTL1PPP1CASMN1; SMN2 | |
| SCHEMBL15884046 | 0.72 | SCN9A (0.41) | BRD4KDM4EALDH1A1POLBMGLL | |
| SCHEMBL3375921 | 0.72 | BRD4 (0.48) | BRD4IL2MCL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206136-B2 | Pyrazolyl-based carboxamides I | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-9206136-B2 | Pyrazolyl-based carboxamides I | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| WO-2014108337-A1 | PYRAZOLYL-BASED CARBOXAMIDES I AS CRAC CHANNEL INHIBITORS | Grünenthal GmbH (DE) | 2014-07-17 | — | — | WO | disclosed |
| US-20140194443-A1 | Pyrazolyl-Based Carboxamides I | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194443-A1 | Pyrazolyl-Based Carboxamides I | AADAC, HDAC3, NLRP3 | BRD4 74/4885KDM4E 2094/4885ALDH1A1 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.