Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.52 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230313 | 0.82 | P2RX7 (0.54) | P2RX7TSHRALDH1A1HSD17B10 | |
| SCHEMBL1900019 | 0.81 | P2RX7 (0.51) | P2RX7TSHRALDH1A1USP5HSD17B10 | |
| SCHEMBL5135477 | 0.78 | P2RX7 (0.41) | P2RX7ELANEKDM4ENR4A1NR4A2 | |
| SCHEMBL15869588 | 0.78 | P2RX7 (0.41) | P2RX7ELANEKDM4ENR4A1NR4A2 | |
| SCHEMBL2502255 | 0.77 | P2RX7 (0.39) | P2RX7ELANEKDM4ENR4A1NR4A2 | |
| SCHEMBL1893962 | 0.77 | P2RX7 (0.48) | P2RX7 | |
| SCHEMBL12675136 | 0.77 | P2RX7 (0.44) | P2RX7KDM4ELMNA | |
| SCHEMBL8069501 | 0.72 | BRD4 (0.51) | KDM4ENR4A1NR4A2NR4A3TSHR | |
| SCHEMBL9394461 | 0.72 | BRD4 (0.51) | ELANEKDM4ENR4A1NR4A2NR4A3 | |
| SCHEMBL1590073 | 0.71 | P2RX7 (0.56) | P2RX7ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937643-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-07-13 | — | — | EP | disclosed |
| US-8779144-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2014-07-15 | — | — | US | disclosed |