Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15869659 | 1.00 | SIGMAR1 (0.50) | SIGMAR1HTR3AADORA3PIK3CGHTR1A | |
| SCHEMBL15869658 | 1.00 | SIGMAR1 (0.50) | SIGMAR1HTR3AADORA3PIK3CGHTR1A | |
| SCHEMBL15869581 | 0.95 | SIGMAR1 (0.57) | SIGMAR1ADORA3 | |
| SCHEMBL15869580 | 0.95 | SIGMAR1 (0.57) | SIGMAR1ADORA3 | |
| SCHEMBL15869644 | 0.95 | SIGMAR1 (0.57) | SIGMAR1ADORA3 | |
| SCHEMBL15869717 | 0.77 | SIGMAR1 (0.45) | SIGMAR1ADORA3PIK3CGHTR1ASLC6A2 | |
| SCHEMBL15869674 | 0.77 | SIGMAR1 (0.45) | SIGMAR1ADORA3PIK3CGHTR1ASLC6A2 | |
| SCHEMBL15869675 | 0.77 | SIGMAR1 (0.45) | SIGMAR1ADORA3PIK3CGHTR1ASLC6A2 | |
| SCHEMBL31153240 | 0.69 | ADORA3 (0.48) | ADORA3PIK3CG | |
| SCHEMBL25634132 | 0.69 | ADORA3 (0.48) | ADORA3PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | claimed |
| US-8778959-B2 | AZA-bridged ring-fused indoles and indolines | ABBVIE INC. (US) | 2014-07-15 | — | — | US | disclosed |