Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 14/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769604 | 0.87 | CYP11B1 (0.40) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL769027 | 0.86 | CYP11B2 (0.41) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL15869740 | 0.83 | CYP11B1 (0.39) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL750894 | 0.81 | BMPR1A (0.40) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL769387 | 0.81 | LMNA (0.41) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL15869737 | 0.80 | CYP11B1 (0.38) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL769240 | 0.80 | CYP11B1 (0.41) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL749146 | 0.79 | BMPR1A (0.40) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL769004 | 0.79 | CYP11B2 (0.44) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 | |
| SCHEMBL777743 | 0.78 | CYP11B2 (0.46) | CYP11B2CYP11B1BMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778972-B2 | 5-pyridin-3-yl-1, 3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1 | NOVARTIS AG (CH) | 2014-07-15 | — | — | US | disclosed |