⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448266 | 0.83 | CNR1 (0.48) | — | |
| SCHEMBL11134188 | 0.79 | NPC1 (0.50) | — | |
| SCHEMBL5504193 | 0.79 | — | — | |
| SCHEMBL27864547 | 0.78 | PTGS2 (0.50) | — | |
| SCHEMBL27710067 | 0.77 | — | — | |
| SCHEMBL11597445 | 0.77 | PTGS2 (0.52) | — | |
| SCHEMBL7055467 | 0.77 | PTGS2 (0.52) | — | |
| SCHEMBL15067982 | 0.76 | TRPA1 (0.39) | — | |
| SCHEMBL10460435 | 0.76 | KDM4E (0.48) | — | |
| SCHEMBL455762 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1064 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397366-A2 | GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA | Ardelyx, Inc. (US) | 2024-07-10 | — | — | EP | disclosed |
| US-20240209019-A1 | COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA | ARDELYX, INC. (US) | 2024-06-27 | — | — | US | disclosed |
| EP-3682873-B1 | SMAC MIMETICS FOR USE IN THE TREATMENT OF PERSISTENT HIV INFECTION | WALTER & ELIZA HALL INST MEDICAL RES (AU) | 2024-06-12 | — | — | EP | disclosed |
| US-RE49934-E1 | Inhibitors of cellular metabolic processes | SERVIER PHARMACEUTICALS LLC (US) | 2024-04-23 | — | — | US | disclosed |
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2024-04-11 | — | — | US | disclosed |
| EP-3661945-B1 | GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA | ARDELYX INC (US) | 2024-04-03 | — | — | EP | disclosed |
| US-11858959-B2 | Glycyrrhetinic acid derivatives for use in treating hyperkalemia | ARDELYX, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-20230390246-A1 | Compounds and Compositions That Bind and Stabilize Transthyretin and Their Use for Inhibiting Transthyretin Amyloidosis and Protein-Protein Interactions | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2023-12-07 | — | — | US | disclosed |
| US-11795170-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2023-10-24 | — | — | US | disclosed |
| US-11768319-B2 | Glycyrrhetinic acid derivatives for treating hyperkalemia | ARDELYX, INC. (US) | 2023-09-26 | — | — | US | disclosed |
| EP-0037729-A2 | Process for penicillin epimerization | ELI LILLY AND COMPANY (US) | 1981-10-14 | — | — | EP | disclosed |
| US-4293493-A | Azetidinone alcohol disulfides and process for cyclization | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4293495-A | Symmetrical azetidinone aldehyde disulfides and process | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4147739-A | Thermoplastic molding compositions of rubber modified copolymers of a vinyl aromatic compound and an α,β-unsaturated cyclic anhydride | GENERAL ELECTRIC COMPANY (US) | 1979-04-03 | — | — | US | disclosed |
| US-4113797-A | BLOCK POLYMERS | GENERAL ELECTRIC COMPANY (US) | 1978-09-12 | — | — | US | disclosed |
| US-4077934-A | Method of preparing compositions that comprise a polyphenylene ether resin and an alkenyl aromatic resin | GENERAL ELECTRIC COMPANY (US) | 1978-03-07 | — | — | US | disclosed |
| US-4060688-A | Cephalosporin intermediates | ELI LILLY AND COMPANY (US) | 1977-11-29 | — | — | US | disclosed |
| US-4012380-A | 7-Acylamino-3-acyl-2(or 3)cephems | ELI LILLY AND COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-4001226-A | 3-(SUBSTITUTED)CARBONYLAMINO CEPHEM DERIVATIVES | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3953436-A | 3,4-Dicarboxycephalosporins and derivatives | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |